Guy S Salvesen Selected Research

Proteins (Proteins, Gene)

10/2018	Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes.
6/2015	SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML.
1/2015	Probes to monitor activity of the paracaspase MALT1.
4/2013	Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.
4/2012	Mechanism and specificity of the human paracaspase MALT1.
1/2012	Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
9/2011	Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
3/2011	Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
11/2010	Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.
10/2004	Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.

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Guy S Salvesen Research Topics

Disease

11	Neoplasms (Cancer) 01/2020 - 02/2004
9	Inflammation (Inflammations) 03/2022 - 12/2006
6	Necrosis 01/2019 - 01/2002
3	Neoplasm Metastasis (Metastasis) 09/2019 - 02/2004
3	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 10/2018 - 04/2012
3	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2015 - 01/2002
2	Retinal Vein Occlusion 01/2020 - 01/2020
2	Ischemia 01/2020 - 10/2004
2	Breast Neoplasms (Breast Cancer) 02/2018 - 04/2010
2	Infections 01/2017 - 01/2009
2	Melanoma (Melanoma, Malignant) 04/2013 - 01/2005
1	Multiple Myeloma 01/2022
1	von Hippel-Lindau Disease (von Hippel Lindau Disease) 01/2022
1	Bicuspid Aortic Valve Disease 01/2022
1	Zoonoses 01/2021
1	Geographic Atrophy 01/2020
1	Macular Degeneration (Age-Related Maculopathy) 01/2020
1	Confusion (Bewilderment) 01/2020
1	Papilledema 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Disease Progression 01/2020
1	Colonic Neoplasms (Colon Cancer) 12/2019
1	Parasitic Diseases (Parasitic Disease) 10/2019
1	Schistosomiasis (Bilharziasis) 10/2019
1	Gout 01/2019
1	Carcinogenesis 02/2018
1	Septic Shock (Toxic Shock Syndrome) 10/2015
1	Acute Promyelocytic Leukemia 06/2015
1	Genetic Translocation (Chromosomal Translocation) 06/2015
1	Vaccinia 11/2012
1	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2012
1	Malaria 01/2012
1	Stroke (Strokes) 06/2011
1	Huntington Disease (Huntington's Disease) 11/2010
1	Severe Acute Respiratory Syndrome 11/2008
1	Cowpox 12/2006

Drug/Important Bio-Agent (IBA)

17	CaspasesIBA 03/2022 - 01/2002
12	Peptide Hydrolases (Proteases)FDA Link 10/2019 - 10/2004
10	Proteins (Proteins, Gene)FDA Link 10/2018 - 10/2004
4	EnzymesIBA 01/2021 - 02/2004
3	Caspase 9IBA 01/2020 - 06/2011
3	Biological ProductsIBA 01/2020 - 03/2011
3	Pharmaceutical PreparationsIBA 10/2019 - 09/2010
3	Fluorescent Dyes (Fluorescent Probes)IBA 09/2019 - 01/2012
2	CytokinesIBA 01/2022 - 01/2009
2	CathepsinsIBA 09/2019 - 02/2018
2	Cysteine Proteases (Cysteine Protease)IBA 10/2018 - 01/2002
2	Cysteine (L-Cysteine)FDA Link 02/2018 - 01/2014
2	Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinIBA 01/2015 - 04/2012
2	Initiator CaspasesIBA 06/2011 - 12/2006
2	LigandsIBA 03/2011 - 04/2010
2	AntibodiesIBA 04/2010 - 10/2004
2	Matrix Metalloproteinase 14 (MT1-MMP)IBA 10/2007 - 02/2004
2	Apoptosis Regulatory ProteinsIBA 01/2005 - 10/2004
1	Metalloproteases (Metalloproteinases)IBA 01/2022
1	InflammasomesIBA 01/2021
1	HydrolasesIBA 01/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	Serine (L-Serine)FDA Link 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Caspase 7IBA 01/2020
1	Caspase 2IBA 12/2019
1	2- (4- morpholinoanilino)- 6- cyclohexylaminopurineIBA 12/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2019
1	Cathepsin BIBA 09/2019
1	Cathepsin GIBA 01/2019
1	Uric Acid (Urate)IBA 01/2019
1	Cathepsin LIBA 02/2018
1	ProteomeIBA 02/2018
1	Serine Proteases (Serine Protease)IBA 01/2017
1	LipopolysaccharidesIBA 10/2015
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 06/2015
1	Oncogene Proteins (Oncogene Protein)IBA 06/2015
1	Arsenic Trioxide (Trisenox)FDA Link 06/2015
1	Promyelocytic Leukemia ProteinIBA 06/2015
1	Viral ProteinsIBA 11/2012
1	Inhibitor of Apoptosis ProteinsIBA 04/2012
1	B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA 04/2012
1	AminopeptidasesIBA 01/2012
1	Amino Acids FDA Link 01/2012
1	Exopeptidases (Exopeptidase)IBA 01/2012
1	Death Domain ReceptorsIBA 09/2011
1	Fas-Associated Death Domain Protein (Fas-Associating Protein with Death Domain)IBA 09/2011
1	Caspase 8 (Caspase-8)IBA 03/2011
1	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA 03/2011
1	Glutamine (L-Glutamine)FDA Link 11/2010
1	Caspase InhibitorsIBA 11/2010
1	adhesion receptorIBA 04/2010
1	Integrin alphaVbeta3IBA 04/2010
1	Single-Chain AntibodiesIBA 04/2010
1	Ubiquitin-Specific ProteasesIBA 11/2008
1	PapainIBA 11/2008
1	UbiquitinIBA 11/2008
1	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 11/2008
1	isopeptidaseIBA 11/2008
1	Collagenases (Collagenase)FDA Link 10/2007
1	SerpinsIBA 12/2006
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2005

Therapy/Procedure

2	Therapeutics 04/2010 - 04/2004
1	Drug Therapy (Chemotherapy) 06/2015